Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro
نویسندگان
چکیده
منابع مشابه
Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma
PBMC from 11 patients with multiple myeloma (MM) were cultured in vitro in presence of IL-3 and IL-6. After 3 d, actively proliferating immunoblast-like B cells (20-62%) were apparent. After 6 d, a population of morphologically evident plasma cells was observed (30-50%) that expressed, in each individual case, the same light and heavy chain produced by bone marrow malignant plasma cells. We con...
متن کاملRecombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro.
Recombinant gibbon interleukin-3 (IL-3) is a multilineage hematopoietic colony-stimulating factor (CSF) that recently was cloned and found to be highly homologous with human IL-3. Gibbon IL-3, as well as human granulocyte-CSF (G-CSF) and human granulocyte-macrophage CSF (GM-CSF), stimulated normal human bone marrow cells to form myeloid colonies in soft agar in a sigmoidal dose-response manner....
متن کاملInterleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.
Certain cytokines have been reported to exert neurotrophic actions in vivo and in vitro. In the present study, we investigated the possible neuroprotective actions of the cytokine human recombinant interleukin-1 beta (hrIL-1 beta) against excitatory amino acid (EAA)-induced neurodegeneration in cultured primary cortical neurons. Brief (15 min) exposure of cultures to submaximal concentrations o...
متن کامل5. Interleukin-3 Promotes Neurite Outgrowth and Elevates Choline Acetyltrans f erase Activity in vitro
Introduction. Central cholinergic neurons are reported to be important in memory acquisition and are known to degenerate in Alzheimer's disease.l) Since nerve growth factor (NGF) was found to increase choline acetyltransf erase (ChAT) activity''),.) and prevent cholinergic neuron death,4)-°~ investigators started to look for other neurotrophic factors for these neurons. So far, fibroblast growt...
متن کاملSoluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth
BACKGROUND The cleavage of β-amyloid precursor protein (APP) generates multiple proteins: Soluble β-amyloid Precursor Protein Alpha (sAPPα), sAPPβ, and amyloid β (Aβ). Previous studies have shown that sAPPα and sAPPβ possess neurotrophic properties, whereas Aβ is neurotoxic. However, the underlying mechanism of the opposing effects of APP fragments remains poorly understood. In this study, we h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2011
ISSN: 1742-2094
DOI: 10.1186/1742-2094-8-183